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Publications

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Highlights

Identification of an Immune-Neuroendocrine Biomarker Panel for Detection of Depression: A Joint Effects Statistical Approach.
Neuroendocrinology. 2015 November 19. PMID: 26580065

Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset. 
Transl Psychiatry. 2015 July 14; 5:e601.  PMID: 26171982

Neuroimmune biomarkers in schizophrenia.
Schizophr Res. 2014 Aug 11. pii: S0920-9964(14)00382-X.  PubMed PMID: 25124519 

Distinct molecular phenotypes in male and female schizophrenia patients.
PLoS One. 2013 Nov 11;8(11):e78729.   PubMed PMID: 24244349  

Identification of Subgroups of Schizophrenia Patients With Changes in Either Immune or Growth Factor and Hormonal Pathways.
Schizophr Bull. 2013 Aug 9.  PMID:23934781 

Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients.
Mol Psychiatry. 2010 Oct 5. Pubmed PMID: 20921955

Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients
Mol Psychiatry. 2010 Jun 29. PubMed PMID: 20585325

Differential effects on T-cell function following exposure to serum from schizophrenia smokers.
Mol Psychiatry. 2008 Nov 11.  PubMed PMID: 19002140

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. 
Mol Psychiatry. 2004 Jul;9(7):684-97, 643 pubmed PMID: 15098003

Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Lancet. 2003 Sep 6;362(9386):798-805 pubmed PMID: 13678875

2016

Cox DA, Gottschalk MG, Stelzhammer V, Wesseling H, Cooper JD, Bahn S.
Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: a proteomic systems approach. World J Biol Psychiatry. 2016 Oct 27:1-31. [Epub ahead of print] PMID: 27784204

Chan MK, Cooper JD, Bot M, Birkenhager TK, Bergink V, Drexhage HA, Steiner J, Rothermundt M, Penninx BW, Bahn S.
Blood-based immune-endocrine biomarkers of treatment response in depression. J Psychiatr Res. 2016 Aug 31;83:249-259. [Epub ahead of print] PMID: 27693950

Xia M, Broek JA, Jouroukhin Y, Schoenfelder J, Abazyan S, Jaaro-Peled H, Sawa A, Bahn S, Pletnikov M.
Cell Type-Specific Effects of Mutant DISC1: A Proteomics Study. Mol Neuropsychiatry. 2016 May;2(1):28-36. PMID: 27606318

Knöchel C, Kniep J, Cooper JD, Stäblein M, Wenzler S, Sarlon J, Prvulovic D, Linden DE, Bahn S, Stocki P, Ozcan S, Alves G, Carvalho AF, Reif A, Oertel-Knöchel V.
Altered apolipoprotein C expression in association with cognition impairments and hippocampus volume in schizophrenia and bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2016 Aug 22. [Epub ahead of print] PMID: 27549216

Lamers F, Bot M, Jansen R, Chan MK, Cooper JD, Bahn S, Penninx BW.
Serum proteomic profiles of depressive subtypes. Transl Psychiatry. 2016 Jul 12;6(7):e851.PMID: 27404283

Cox DA, Gottschalk MG, Wesseling H, Ernst A, Cooper JD, Bahn S.
Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology. Schizophr Res. 2016 Jun 19. pii: S0920-9964(16)30279-1. [Epub ahead of print] PMID: 2733518

Ruland T, Chan MK, Stocki P, Grosse L, Rothermundt M, Cooper JD, Arolt V, Bahn S.
Molecular serum signature of treatment resistant depression. Psychopharmacology (Berl). 2016 Aug;233(15-16):3051-9. PMID: 27325393

Vogelzangs N, de Jonge P, Smit JH, Bahn S, Penninx BW.
Cytokine production capacity in depression and anxiety. Transl Psychiatry. 2016 May; 6(5): e825. PMID: 27244234

Ramsey JM, Cooper JD, Penninx BW, Bahn S.
Variation in serum biomarkers with sex and female hormonal status: implications for clinical tests. Sci Rep. 2016 May; 6: 26947. PMID: 27240929

Ramsey JM, Cooper JD, Bot M, Guest PC, Lamers F, Weickert CS, Penninx BW, Bahn S. 
Sex Differences in Serum Markers of Major Depressive Disorder in the Netherlands Study of Depression and Anxiety (NESDA). PLoS One. 2016 May; 11(5): e0156624. PMID: 27232630

Wesseling H, Xu B, Want EJ, Holmes E, Guest PC, Karayiorgou M, Gogos JA, Bahn S.
System-based proteomic and metabonomic analysis of the Df(16)A+/- mouse identifies potential miR-185 targets and molecular pathway alterations. Mol Psychiatry. 2016 Mar. PMID: 27001617

Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB.
Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia.Schizophr Bull. 2016 Mar;42(2):386-95. PMID: 26392628

Broek JA, Lin Z, de Gruiter HM, van 't Spijker H, Haasdijk ED, Cox D, Ozcan S, van Cappellen GW, Houtsmuller AB, Willemsen R, de Zeeuw CI, Bahn S.
Synaptic vesicle dynamic changes in a model of fragile X. Mol Autism.2016 Mar; 7: 17. PMID: 26933487

Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S.
Serum biomarkers predictive of depressive episodes in panic disorder. J Psychiatr Res.2016 Feb; 73: 53-62. PMID: 26687614

2015

Haenisch F, Alsaif M, Guest PC, Rahmoune H, Yolken RH, Dickerson F, Bahn S.
Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients. J Affect Disord. 2015 October 1; 185:12-6. PMID: 26142689

Chan MK, Cooper JD, Bahn S.
Commercialisation of Biomarker Tests for Mental Illnesses: Advances and Obstacles. Trends Biotechnol. 2015 December; 33(12):712-23. PMID: 26549771

Gottschalk MG, Cooper JD, Chan MK, Bot M, Penninx BW, Bahn S.
Serum biomarkers predictive of depressive episodes in panic disorder. J Psychiatr Res. 2015 Nov 24; 73: 53-62. PMID: 26687614

Chan MK, Cooper JD, Bot M, Steiner J, Penninx BW, Bahn S. 
Identification of an Immune-Neuroendocrine Biomarker Panel for Detection of Depression: A Joint Effects Statistical Approach. Neuroendocrinology. 2015 November 19. PMID: 26580065

Tomasik J, Schwarz E, Lago SG, Rothermundt M, Leweke FM, van Beveren NJ, Guest PC, Rahmoune H, Steiner J, Bahn S.
Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients. Brain Behav Immun. 2015 November 2. pii: S0889-1591(15)30045-3. PMID: 26541453

Haenisch F, Cooper JD, Reif A, Kittel-Schneider S, Steiner J, Leweke FM, Rothermundt M, van Beveren NJ, Crespo-Facorro B, Niebuhr DW, Cowan DN, Weber NS, Yolken RH, Penninx BW, Bahn S.
Towards a blood-based diagnostic panel for bipolar disorder. Brain Behav Immun. 2015 October 13. pii: S0889-1591(15)30027-1. PMID: 26441135

Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB. 
Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia.Schizophr Bull.2015 September 20. pii: sbv134. PMID: 26392628

Dickerson F, Schroeder J, Stallings C, Origoni A, Bahn S, Yolken R.
Multianalyte markers of schizophrenia and bipolar disorder: A preliminary study. Schizophr Res. 2015 October; 168(1-2):450-5. PMID: 26298538

Sabunciyan S, Maher B, Bahn S, Dickerson F, Yolken RH.
Association of DNA Methylation with Acute Mania and Inflammatory Markers.PLoS One. 2015 July 6; 10(7):e0132001. PMID: 26147665

Haenisch F, Alsaif M, Guest PC, Rahmoune H, Yolken RH, Dickerson F, Bahn S.
Multiplex immunoassay analysis of plasma shows differences in biomarkers related to manic or mixed mood states in bipolar disorder patients. J Affect Disord. 2015 October 1; 185:12-6. PMID: 26142689

Dickerson F, Schroeder J, Stallings C, Origoni A, Bahn S, Yolken R.
Multianalyte markers of schizophrenia and bipolar disorder: A preliminary study. Schizophr Res. 2015 August 19. PMID: 26298538

Wesseling H, Want EJ, Guest PC, Rahmoune H, Holmes E, Bahn S.
Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model. J Proteome Res. 2015 August 7; 14(8):3174-87. PMID: 26043028

Chan MK, Krebs MO, Cox D, Guest PC, Yolken RH, Rahmoune H, Rothermundt M, Steiner J, Leweke FM, van Beveren NJ, Niebuhr DW, Weber NS, Cowan DN, Suarez-Pinilla P, Crespo-Facorro B, Mam-Lam-Fook C, Bourgin J, Wenstrup RJ, Kaldate RR, Cooper JD, Bahn S.
Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset. Transl Psychiatry. 2015 July 14; 5:e601. PMID: 26171982

Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BW.
Serum proteomic profiling of major depressive disorder. Transl Psychiatry. 2015 July 14; 5:e599. PMID: 26171980

Sabunciyan S, Maher B, Bahn S, Dickerson F, Yolken RH.
Association of DNA Methylation with Acute Mania and Inflammatory Markers. PLoS One.  2015 Jul 6; 10(7):e0132001. PMID: 26147665

Tomasik J, Yolken RH, Bahn S, Dickerson FB.
Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial. Biomark Insights. 2015 June 1. PMID: 26052224

Cox D, Chan MK, Bahn S.
The potential of immune biomarkers to advance personalized medicine approaches for schizophrenia. J Nerv Ment Dis. 2015 May; 203(5):393-9. PMID: 25919386

Scarr E, Millan MJ, Bahn S, Bertolino A, Turck CW, Kapur S, Möller HJ, Dean B.
Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank. Int J Neuropsychopharmacol.  2015 April 21. PMID: 25899066

Jaros JA, Rahmoune H, Wesseling H, Leweke FM, Ozcan S, Guest PC, Bahn S.
Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia. Proteomics Clin Appl.  2015 March 27. PMID: 25821032

Bahn S, Chan MK.
What can we learn about depression from gene expression in peripheral tissues? Biol Psychiatry. 2015 February  1; 77(3):207-9. PMID: 25542515

 

2014

Wesseling H. Gottschalk MG, Bahn S.
Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders. Int J Neuropsychopharmacol. 2014 Oct 31;18(1). PMID: 25539505

Gottschalk MG, Wesseling H, Guest PC, Bahn S.
Proteomic enrichment analysis of psychotic and affective disorders reveals common signatures in presynaptic glutamatergic signaling and energy Metabolism. Int J Neuropsychopharmacol. 2014 Oct 31; 18(2). PMID: 25609598

Wesseling H, Rahmoune H, Tricklebank M, Guest PC, Bahn S.
A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain. J Proteome Res. 2014 Nov 2. PMID: 25363195

Chan MK, Gottschalk MG, Haenisch F, Tomasik J, Ruland T, Rahmoune H, Guest PC, Bahn S.
Applications of blood-based protein biomarker strategies in the study of psychiatric disorders. Prog Neurobiol. 2014 Aug 27. pii: S0301-0082(14)00090-2. doi: 10.1016/j.pneurobio.2014.08.002. [Epub ahead of print] Review. [ PubMed PMID: 25173695 ]

van Beveren NJ, Schwarz E, Noll R, Guest PC, Meijer C, de Haan L, Bahn S.
Evidence for disturbed insulin and growth hormone signaling as potential risk factors in the development of schizophrenia. Transl Psychiatry. 2014 Aug 26;4:e430. doi: 10.1038/tp.2014.52. [ PubMed PMID: 25158005 ]

Agarwal A, Zhang M, Trembak-Duff I, Unterbarnscheidt T, Radyushkin K, Dibaj P, Martins de Souza D, Boretius S, Brzózka MM, Steffens H, Berning S, Teng Z, Gummert MN, Tantra M, Guest PC, Willig KI, Frahm J, Hell SW, Bahn S, Rossner MJ, Nave KA, Ehrenreich H, Zhang W, Schwab MH.
Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell Rep. 2014 Aug 21;8(4):1130-45. doi: 10.1016/j.celrep.2014.07.026. Epub 2014 Aug 14. [PubMed PMID: 25131210]

Broek JA, Guest PC, Rahmoune H, Bahn S.
Proteomic analysis of post mortem brain tissue from autism patients: evidence for opposite changes in prefrontal cortex and cerebellum in synaptic connectivity-related proteins. Mol Autism. 2014 Jul 30;5:41. doi: 10.1186/2040-2392-5-41. eCollection 2014. [ PubMed PMID: 25126406 ]; PubMed Central PMCID: PMC4131484.

Tomasik J, Rahmoune H, Guest PC, Bahn S.
Neuroimmune biomarkers in schizophrenia. Schizophr Res. 2014 Aug 11. pii: S0920-9964(14)00382-X. doi: 10.1016/j.schres.2014.07.025. [Epub ahead of print] Review. [ PubMed PMID: 25124519 ]

Wesseling H, Guest PC, Lee CM, Wong EH, Rahmoune H, Bahn S.
Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders. Mol Autism. 2014 Jul 4;5:38. doi: 10.1186/2040-2392-5-38. eCollection 2014. [ PubMed PMID: 25061506 ]; PubMed Central PMCID: PMC4109791.

Stelzhammer V, Haenisch F, Chan MK, Cooper JD, Steiner J, Steeb H, Martins-de-Souza D, Rahmoune H, Guest PC, Bahn S.
Proteomic changes in serum of first onset, antidepressant drug-naïve major depression patients. Int J Neuropsychopharmacol. 2014 Jun 5:1-10. [Epub ahead of print] [PubMed PMID:24901538]

de Witte L, Tomasik J, Schwarz E, Guest PC, Rahmoune H, Kahn RS, Bahn S.
Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment. Schizophr Res. 2014 Apr;154(1-3):23-9. doi:
10.1016/j.schres.2014.02.005. Epub 2014 Feb 26. [ PubMed PMID: 24582037 ]

Wesseling H, Guest PC, Lago SG, Bahn S. Technological advances for deciphering the complexity of psychiatric disorders: merging proteomics with cell biology. Int J Neuropsychopharmacol. 2014 Aug;17(8):1327-41. doi:
10.1017/S146114571400008X. Epub 2014 Feb 14. [ PubMed PMID: 24524332 ]

Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S. Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome. Mol Autism. 2014 Jan 27;5(1):4. doi:10.1186/2040-2392-5-4. [ PubMed PMID: 24467795 ]; PubMed Central PMCID: PMC3905921.

 

2013

Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S.
Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3β signaling in bipolar patients. J Affect Disord. 2014 Mar;156:139-43. doi: 0.1016/j.jad.2013.12.008. Epub 2013 Dec 16. [ PubMed PMID: 24411062 ]

Guest PC, Chan MK, Gottschalk MG, Bahn S. The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients. Biomark Med. 2014 Jan;8(1):15-27. doi: 10.2217/bmm.13.83. Review. [PubMed PMID: 24325222]

Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S.
Distinct molecular phenotypes in male and female schizophrenia patients. PLoS One. 2013 Nov 11;8(11):e78729. doi:
10.1371/journal.pone.0078729. eCollection 2013. [ PubMed PMID: 24244349 ] PubMed Central PMCID: PMC3823995.

Broek JA, Brombacher E, Stelzhammer V, Guest PC, Rahmoune H, Bahn S. The need for a comprehensive molecular characterization of autism spectrum disorders. Int J Neuropsychopharmacol. 2014 Apr;17(4):651-73. doi: 10.1017/S146114571300117X. Epub 2013 Nov 12. PubMed PMID: 24229490.

Schwarz E, Steiner J, Guest PC, Bogerts B, Bahn S.
Investigation of molecular serum profiles associated with predisposition to antipsychotic-induced weight gain. World J Biol Psychiatry. 2013 Sep 3. [Epub ahead of print] PubMed PMID: 24001020.

Albrecht, A, Rahmoune, H, Leedjärv, K, Knorpp, T, Joos, T, Stocki, P, Guest, PC, Bahn, S
Development of a novel assay for proprotein converting enzyme activity on a multiplex bead-based array system.
Proteomics 13, 20:2976-9. [ PMID: 23970482 ]

Deng J, Lamb JR, McKeown AP, Miller S, Muglia P, Guest PC, Bahn S, Domenici EH, Rahmoune H.
Identification of altered dipeptidyl-peptidase activities as potential biomarkers for unipolar depression.
J Affect Disord. 2013 Jul 31. pii: S0165-0327(13)00568-5. doi: 10.1016/j.jad.2013.07.015. [Epub ahead of print] [ PMID:23948634 ]

Wesseling H, Chan MK, Tsang TM, Ernst A, Peters F, Guest PC, Holmes E, Bahn S.
A Combined Metabonomic and Proteomic Approach Identifies Frontal Cortex Changes in a Chronic Phencyclidine Rat Model in Relation to Human Schizophrenia Brain Pathology.
Neuropsychopharmacology. 2013 Jul 3. doi: 10.1038/npp.2013.160. [Epub ahead of print] [ PMID:23942359 ]

Schwarz E, van Beveren NJ, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S.
Identification of Subgroups of Schizophrenia Patients With Changes in Either Immune or Growth Factor and Hormonal Pathways.
Schizophr Bull. 2013 Aug 9. [Epub ahead of print] [ PMID:23934781 ]

Ramsey JM, Guest PC, Broek JA, Glennon JC, Rommelse N, Franke B, Rahmoune H, Buitelaar JK, Bahn S.
Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders.
Mol Autism. 2013 Aug 6;4(1):27. doi: 10.1186/2040-2392-4-27. [ PMID:23915542 ]

Jaros JA, Guest PC, Bahn S, Martins-de-Souza D.
Affinity depletion of plasma and serum for mass spectrometry-based proteome analysis. 
Methods Mol Biol. 2013;1002:1-11. doi: 10.1007/978-1-62703-360-2_1. [ PMID:23625390 ]

Amess B, Kluge W, Schwarz E, Haenisch F, Alsaif M, Yolken RH, Leweke FM, Guest PC, Bahn S.
Application of meta-analysis methods for identifying proteomic expression level differences. 
Proteomics. 2013 Apr 14. doi: 10.1002/pmic.201300034. [Epub ahead of print] [ PMID:23585424 ]

Guest PC, Martins-de-Souza D, Schwarz E, Rahmoune H, Alsaif M, Tomasik J, Turck CW, Bahn S.
Proteomic profiling in schizophrenia: enabling stratification for more effective treatment.
Genome Med. 2013 Mar 26;5(3):25. [Epub ahead of print] [ PMID:23531373 ]

Guest PC, Gottschalk MG, Bahn S.
Proteomics: improving biomarker translation to modern medicine?
Genome Med. 2013 Feb 27;5(2):17. [Epub ahead of print] [ PMID:23445684 ]

Alsaif M, Haenisch F, Guest PC, Rahmoune H, Bahn S.
Challenges in drug target discovery in bipolar disorder.
Expert Opin Ther Targets. 2013 May;17(5):565-77. doi: 10.1517/14728222.2013.771169. Epub 2013 Feb 18. [ PMID:23419165 ]

Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S.
Identification of a molecular profile associated with immune status in first onset schizophrenia patients.
Clin Schizophr Relat Psychoses. 2013 Feb 8:1-14. [Epub ahead of print] [ PMID:23395839 ]

 

2012

Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Ruta L, Baron-Cohen S, Bahn S.
Molecular sex differences in human serum.
PLoS One. 2012;7(12):e51504. doi: 10.1371/journal.pone.0051504. Epub 2012 Dec 12. [ PMID:23251558 ]

Stelzhammer V, Guest PC, Rothermundt M, Sondermann C, Michael N, Schwarz E, Rahmoune H, Bahn S.
Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients.
Eur Neuropsychopharmacol. 2012 Nov 22. pii: S0924-977X(12)00303-3. doi: 10.1016/j.euroneuro.2012.10.012. [Epub ahead of print] [PMID:23183131 ]

Harris LW, Pietsch S, Cheng TM, Schwarz E, Guest PC, Bahn S.
Comparison of peripheral and central schizophrenia biomarker profiles.
PLoS One. 2012;7(10):e46368. doi: 10.1371/journal.pone.0046368. Epub 2012 Oct 30. [PMID:23118852 ]

Harris LW, Guest PC, Wayland MT, Umrania Y, Krishnamurthy D, Rahmoune H, Bahn S.
Schizophrenia: Metabolic aspects of aetiology, diagnosis and future treatment strategies.
Psychoneuroendocrinology. 2012 Oct 18. pii: S0306-4530(12)00325-3. doi: 10.1016/j.psyneuen.2012.09.009. [Epub ahead of print] [PMID:23084727 ]

Guest PC, Urday S, Ma D, Stelzhammer V, Harris LW, Amess B, Pietsch S, Oheim C, Ozanne SE, Bahn S.
Proteomic analysis of the maternal protein restriction rat model for schizophrenia: Identification of translational changes in hormonal signaling pathways and glutamate neurotransmission.
Proteomics. 2012 Oct 16. doi: 10.1002/pmic.201200376. [Epub ahead of print] [PMID:23071080 ]

Stelzhammer V, Amess B, Martins-de-Souza D, Levin Y, Ozanne SE, Martin-Gronert MS, Urday S, Bahn S, Guest PC.
Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS.
Proteomics. 2012 Sep 19. doi: 10.1002/pmic.201100642. [Epub ahead of print] [PMID:22997143 ]

Tomasik J, Schwarz E, Guest PC, Bahn S.
Blood test for schizophrenia.
Eur Arch Psychiatry Clin Neurosci. 2012 Nov;262 Suppl 2:79-83. doi: 10.1007/s00406-012-0354-3. Epub 2012 Aug 26. [PMID:22923188 ]

Alsaif M, Guest PC, Schwarz E, Reif A, Kittel-Schneider S, Spain M, Rahmoune H, Bahn S.
Analysis of serum and plasma identifies differences in molecular coverage, measurement variability, and candidate biomarker selection.
Proteomics Clin Appl. 2012 Jun;6(5-6):297-303. doi: 10.1002/prca.201100061. [PMID:22641612 ]

Jaros JA, Martins-de-Souza D, Rahmoune H, Rothermundt M, Leweke FM, Guest PC, Bahn S.
Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls.
J Proteomics. 2012 May 26. [Epub ahead of print] [PMID:22641159 ]

Ernst A, Ma D, Garcia-Perez I, Tsang TM, Kluge W, Schwarz E, Guest PC, Holmes E, Sarnyai Z, Bahn S.
Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.
J Proteome Res. 2012 Jul 6;11(7):3704-14. Epub 2012 Jun 1. [PMID:22613019 ]

Telford JE, Bones J, McManus C, Saldova R, Manning G, Doherty M, Leweke FM, Rothermundt M, Guest PC, Rahmoune H, Bahn S, Rudd PM.
Antipsychotic treatment of acute paranoid schizophrenia patients with olanzapine results in altered glycosylation of serum glycoproteins.
J Proteome Res. 2012 Jul 6;11(7):3743-52. Epub 2012 May 29. [PMID:22594947 ]

Schwarz E, Torrey EF, Guest PC, Bahn S.
Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases.
Genome Med. 2012 Apr 30;4(4):39. [Epub ahead of print] [PMID:22546850 ]

Martins-de-Souza D, Alsaif M, Ernst A, Harris LW, Aerts N, Lenaerts I, Peeters PJ, Amess B, Rahmoune H, Bahn S, Guest PC.
The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
BMC Res Notes. 2012 Mar 15;5:146. [PMID:22420779 ]

Jaros JA, Guest PC, Ramoune H, Rothermundt M, Leweke FM, Martins-de-Souza D, Bahn S.
Clinical use of phosphorylated proteins in blood serum analysed by immobilised metal ion affinity chromatography and mass spectrometry.
J Proteomics. 2012 Feb 22. [Epub ahead of print] [PMID: 22382090]

Martins-de-Souza D, Guest P, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S.
Proteomic analysis identifies dysfunction in cellular transport, energy and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
J Proteome Res. 2012 Feb 24. [Epub ahead of print] [PMID: 22360420]

Martins-de-Souza D, Guest PC, Vanattou-Saifoudine N, Rahmoune H, Bahn S.
Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function.
Eur Arch Psychiatry Clin Neurosci. 2012 Feb 21. [Epub ahead of print] [PMID: 22350622]

Martins-de-Souza D, Guest PC, Rahmoune H, Bahn S.
Proteomic approaches to unravel the complexity of schizophrenia.
Expert Rev Proteomics. 2012 Feb;9(1):97-108. [PMID: 22292827]

Krishnamurthy D, Harris LW, Levin Y, Koutroukides TA, Rahmoune H, Pietsch S, Vanattou-Saifoudine N, Leweke FM, Guest PC, Bahn S. 
Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects.
World J Biol Psychiatry. 2012 Jan 17. [Epub ahead of print] [PMID: 22248022]

Filiou MD, Martins-de-Souza D, Guest PC, Bahn S, Turck CW.
To label or not to label: Applications of quantitative proteomics in neuroscience research. 
Proteomics. 2012 Jan 13. doi: 10.1002/pmic.201100350. [Epub ahead of print] [PMID: 22247077]

Martins-de-Souza D, Guest PC, Guest FL, Bauder C, Rahmoune H, Pietsch S, Roeber S, Kretzschmar H, Mann D, Baborie A, Bahn S. 
Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses.
Proteomics. 2012 Feb;12(3):500-4. doi: 10.1002/pmic.201100476. Epub 2012 Jan 10. [PMID: 22162416]

Bahn S, Giles M.
Evaluation of the Neurodegenerative Conditions Coordinated Care Program (NCCCP) in Western Australia: barriers to better service provision.
Eval Program Plann. 2012 Feb;35(1):40-6. Epub 2011 Jul 18. [PMID: 22054523]

 

2011

Jaros JA, Martins-de-Souza D, Rahmoune H, Schwarz E, Leweke FM, Guest PC, Bahn S.
Differential phosphorylation of serum proteins reflecting inflammatory changes in schizophrenia patients.
Eur Arch Psychiatry Clin Neurosci. 2011 Dec 15. [Epub ahead of print] [PMID: 22169887]

Bahn S, Noll R, Barnes A, Schwarz E, Guest PC.
Challenges of introducing new biomarker products for neuropsychiatric disorders into the market.
Int Rev Neurobiol. 2011;101:299-327. [PMID: 22050857 ]

Izmailov R, Guest PC, Bahn S, Schwarz E.
Algorithm development for diagnostic biomarker assays.
Int Rev Neurobiol. 2011;101:279-98. [PMID: 22050856 ]

Schwarz E, Vanbeveren NJ, Guest PC, Izmailov R, Bahn S.
The application of multiplexed assay systems for molecular diagnostics.
Int Rev Neurobiol. 2011;101:259-78. [PMID: 22050855 ]

Sarnyai Z, Alsaif M, Bahn S, Ernst A, Guest PC, Hradetzky E, Kluge W, Stelzhammer V, Wesseling H.
Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders.
Int Rev Neurobiol. 2011;101:203-38. [PMID: 22050853 ]

Guest PC, Martins-de-Souza D, Vanattou-Saifoudine N, Harris LW, Bahn S.
Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia.
Int Rev Neurobiol. 2011;101:145-68. [PMID: 22050851 ]

Chan MK, Guest PC, Levin Y, Umrania Y, Schwarz E, Bahn S, Rahmoune H.
Converging evidence of blood-based biomarkers for schizophrenia: An update.
Int Rev Neurobiol. 2011;101:95-144. [PMID: 22050850 ]

Martins-de-Souza D, Guest PC, Vanattou-Saifoudine N, Harris LW, Bahn S.
Proteomic Technologies for Biomarker Studies in Psychiatry: Advances and needs.
Int Rev Neurobiol. 2011;101:65-94. [PMID: 22050849 ]

Stelzhammer V, Rothermundt M, Guest PC, Michael N, Sondermann C, Kluge W, Martins-de-Souza D, Rahmoune H, Bahn S.
Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy.
Proteomics Clin Appl. 2011 Oct 17. doi: 10.1002/prca.201100040. [Epub ahead of print] [PMID: 22006837 ]

Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TM, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD, Bahn S.
The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus.
Neuropsychopharmacology. 2011 Sep 28. doi: 10.1038/npp.2011.219. [Epub ahead of print] [PMID: 21956444 ]

Schwarz E, Guest PC, Rahmoune H, Martins-de-Souza D, Niebuhr DW, Weber NS, Cowan DN, Yolken RH, Spain M, Barnes A, Bahn S.
Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation.
World J Biol Psychiatry. 2011 Sep 22. [Epub ahead of print] [PMID: 21936765 ]

Bahn S, Schwarz E.
Serum-based biomarkers for psychiatric disorders.
Nervenarzt. 2011 Sep 10. [Epub ahead of print] German. [PMID: 21909807 ]

Kluge W, Alsaif M, Guest PC, Schwarz E, Bahn S.
Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders.
Expert Rev Mol Diagn. 2011 Sep;11(7):721-33. [PMID: 21902534 ]

Koutroukides TA, Guest PC, Leweke FM, Bailey DM, Rahmoune H, Bahn S, Martins-de-Souza D.
Characterization of the human serum depletome by label-free shotgun proteomics.
J Sep Sci. 2011 Jul;34(13):1621-6. doi: 10.1002/jssc.201100060. Epub 2011 Jun 3. [PMID: 21644252 ]

Martins-de-Souza D, Guest PC, Vanattou-Saifoudine N, Wesseling H, Rahmoune H, Bahn S.
The need for phosphoproteomic approaches in psychiatric research.
J Psychiatr Res. 2011 Oct;45(10):1404-6. Epub 2011 May 26. No abstract available. [PMID: 21616503 ]

Martins-de-Souza D, Guest PC, Steeb H, Pietsch S, Rahmoune H, Harris LW, Bahn S.
Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometry.
Proteomics. 2011 Jun;11(11):2347-53. doi: 10.1002/pmic.201000718. Epub 2011 May 2. [PMID: 21538886 ]

Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S.
Identification of a biological signature for schizophrenia in serum.
Mol Psychiatry. 2011 Apr 12. [Epub ahead of print] [PMID: 21483431 ]

Krishnamurthy D, Levin Y, Harris LW, Umrania Y, Bahn S, Guest PC.
Analysis of the human pituitary proteome by data independent label-free liquid chromatography tandem mass spectrometry.
Proteomics. 2011 Feb;11(3):495-500. doi: 10.1002/pmic.201000496. Epub 2011 Jan 11. [Pubmed PMID: 21268279 ]

Yang X, Levin Y, Rahmoune H, Ma D, Schoeffmann S, Umrania Y, Guest PC, Bahn S.
Comprehensive two-dimensional liquid chromatography mass spectrometric profiling of the rat hippocampal proteome.
Proteomics. 2011 Feb;11(3):501-5. doi: 10.1002/pmic.201000525. Epub 2011 Jan 7. [Pubmed PMID: 21268280 ]

Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S.
Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival.
Proteomics. 2011 Jan;11(1):94-105. doi: 10.1002/pmic.201000291. Epub 2010 Dec 6. [Pubmed PMID: 21182197 ]

 

2010

Martins-de-Souza D, Harris LW, Guest PC, Bahn S.
The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics.
Antioxid Redox Signal. 2010 Dec 2. [Epub ahead of print] [Pubmed PMID: 20673161]

Levin Y, Wang L, Schwarz E, Koethe D, Leweke FM, Bahn S.
Global proteomic profiling reveals altered proteomic signature in schizophrenia serum.
Mol Psychiatry. 2010 Nov;15(11):1088-100. Epub 2009 Jun 23. [PubMed PMID: 19546861]

Chan MK, Tsang TM, Harris LW, Guest PC, Holmes E, Bahn S.
Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients.
Mol Psychiatry. 2010 Oct 5. [Epub ahead of print] [Pubmed PMID: 20921955]

Steiner J, Jacobs R, Panteli B, Brauner M, Schiltz K, Bahn S, Herberth M, Westphal S, Gos T, Walter M, Bernstein HG, Myint AM, Bogerts B.
Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity.
Eur Arch Psychiatry Clin Neurosci. 2010 Oct;260(7):509-18. Epub 2010 Jan 27. [PubMed PMID: 20107825]

Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S.
Sex-specific serum biomarker patterns in adults with Asperger's syndrome.
Mol Psychiatry. 2010 Sep 28. [Epub ahead of print] [Pubmed PMID: 20877284]

Martins-de-Souza D, Harris LW, Guest PC, Turck CW, Bahn S
The role of proteomics in depression research.
Eur Arch Psychiatry Clin Neurosci. 2010 Sep;260(6):499-506. Epub 2009 Dec 9. [PubMed PMID: 19997739]

Stanta JL, Saldova R, Struwe WB, Byrne JC, Leweke FM, Rothermund M, Rahnoune H, Levin Y, Guest P, Bahn S, Rudd PM.
Identification of N-glycosylation changes in the CSF and serum in patients with schizophrenia.
J Proteome Res. 2010 Sep 3;9(9):4476-89. [PubMed PMID: 20578731]

Levin Y, Bahn S.
Quantification of proteins by label-free LC-MS/MS.
Methods Mol Biol. 2010;658:217-31. [Pubmed PMID: 20839107]

Giger T, Khaitovich P, Somel M, Lorenc A, Lizano E, Harris LW, Ryan MM, Lan M, Wayland MT, Bahn S, Pääbo S
Evolution of neuronal and endothelial transcriptomes in primates
Genome Biol Evol. 2010 Jul 12;2:284-92. Print 2010. [PubMed PMID: 20624733]

Herberth M, Koethe D, Cheng TM, Krzyszton ND, Schoeffmann S, Guest PC, Rahmoune H, Harris LW, Kranaster L, Leweke FM, Bahn S
Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients
Mol Psychiatry. 2010 Jun 29. [Epub ahead of print] [PubMed PMID: 20585325]

Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, van Beveren NJ, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S.
Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia.
Biomark Insights 2010 May 12;5:39-47. [Pubmed PMID: 20520744]

Cheng TM, Lu YE, Guest PC, Rahmoune H, Harris LW, Wang L, Ma D, Stelzhammer V, Umrania Y, Wayland MT, Li P, Bahn S
Identification of targeted analyte clusters for studies of schizophrenia.
Mol Cell Proteomics. 2010 Mar;9(3):510-22. Epub 2009 Dec 10. [PubMed PMID: 20007949]

Guest PC, Wang L, Harris LW, Burling K, Levin Y, Ernst A, Wayland MT, Umrania Y, Herberth M, Koethe D, van Beveren JM, Rothermundt M, McAllister G, Leweke FM, Steiner J, Bahn S.
Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naive schizophrenia patients.
Mol Psychiatry. 2010 Feb;15(2):118-9. [PubMed PMID: 20098438]

Duncan CE, Webster MJ, Rothmond DA, Bahn S, Elashoff M, Shannon Weickert C.
Prefrontal GABA(A) receptor alpha-subunit expression in normal postnatal human development and schizophrenia.
J Psychiatr Res.. 2010 Jul;44(10):673-81. Epub 2010 Jan 25. [PubMed PMID: 20100621]

Steiner J, Walter M, Guest P, Myint AM, Schiltz K, Panteli B, Brauner M, Bernstein HG, Gos T, Herberth M, Schroeter ML, Schwarz MJ, Westphal S, Bahn S, Bogerts B
Elevated S100B levels in schizophrenia are associated with insulin resistance.
Mol Psychiatry 2010 Jan;15(1):3-4. [PubMed PMID: 20029405]

Wang L, Lockstone HE, Guest PC, Levin Y, Palotás A, Pietsch S, Schwarz E, Rahmoune H, Harris LW, Ma D, Bahn S.
Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia.
J Proteome Res. 2010 Jan;9(1):521-7 [PubMed PMID: 19916557]

Levin Y, Jaros JA, Schwarz E, Bahn S.
Multidimensional protein fractionation of blood proteins coupled to data-independent nanoLC-MS/MS analysis.
J Proteomics. 2010 Jan 3;73(3):689-95. Epub 2009 Nov 5. [PubMed PMID: 19896566]

 

2009

Ma D, Guest PC, Bahn S.
Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis.
Bioanalysis 2009 Dec;1(9):1615-26 [Pubmed PMID: 21083107]

Schwarz E, Leweke FM, Bahn S, Liò P.
Clinical bioinformatics for complex disorders: a schizophrenia case study.
BMC Bioinformatics. 2009 Oct 15;10 Suppl 12:S6. [PubMed PMID: 19828082]

Kim WS, Wong J, Weickert CS, Webster MJ, Bahn S, Garner B. 
Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex.
J Neurochem 2009 May;109(4):1053-66. Epub 2009 Mar 11. [PubMed PMID: 19519777]

Harris LW, Lockstone HE, Khaitovich P, Weickert CS, Webster MJ, Bahn S.
Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia.
BMC Med Genomics. 2009 May 20;2:28. [PubMed PMID: 19457239]

Weickert CS, Elashoff M, Richards AB, Sinclair D, Bahn S, Paabo S, Khaitovich P, Webster MJ
Transcriptome analysis of male-female differences in prefrontal cortical development. 
Mol Psychiatry. 2009 Jun;14(6):558-61. [PubMed PMID: 19455171]

Ma D, Chan MK, Lockstone HE, Pietsch SR, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Umrania Y, Guest PC, Levin Y, Maycox PR, Bahn S.
Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex.
J Proteome Res. 2009 Jul;8(7):3284-97. [PubMed PMID: 19400588]

McLoughlin G, Ma D, Tsang TM, Jones D, Cilia J, Hill M, Robbins M, Benzel I, Maycox P, Holmes E, Bahn S.
Analysing the Effects of Psychotropic Drugs on Metabolite Profiles in Rat Brain Using 1H NMR Spectroscopy.
J Proteome Res. 2009 Apr;8(4):1943-52 [PubMed PMID: 19714815]

Somel M, Franz H, Yan Z, Lorenc A, Guo S, Giger T, Kelso J, Nickel B, Dannemann M, Bahn S, Webster MJ, Weickert CS, Lachmann M, Pääbo S, Khaitovich P.
Transcriptional neoteny in the human brain.
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5743-8. Epub 2009 Mar 23. [PubMed PMID: 19307592 ]

Levin Y, Wang L, Ingudomnukul E, Schwarz E, Baron-Cohen S, Palotás A, Bahn S.
Real-time evaluation of experimental variation in large-scale LC-MS/MS-based quantitative proteomics of complex samples.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1299-305. Epub 2008 Nov 13 [PubMed PMID: 19056327]

 

2008

Harris LW, Wayland M, Lan M, Ryan M, Giger T, Lockstone H, Wuethrich I, Mimmack M, Wang L, Kotter M, Craddock R, Bahn S.
The cerebral microvasculature in schizophrenia: a laser capture microdissection study.
PLoS ONE. 2008;3(12):e3964. Epub 2008 Dec 17. [PubMed PMID: 19088852]

Herberth M, Krzyszton DN, Koethe D, Craddock MR, Bulger E, Schwarz E, Guest P, Leweke FM, Bahn S.
Differential effects on T-cell function following exposure to serum from schizophrenia smokers.
Mol Psychiatry. 2008 Nov 11. [Epub ahead of print] [PubMed PMID: 19002140]

Schwarz E, Prabakaran S, Whitfield P, Major H, Leweke FM, Koethe D, McKenna P, Bahn S.
High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides.
J Proteome Res. 2008 Oct;7(10):4266-77. Epub 2008 Sep 9. [PubMed PMID: 18778095]

Herberth, M, Schwarz E, Bahn S.
Problems and promise of immunological factors as biomarkers for schizophrenia.
Biomark Med. 2008 Aug;2(4):385-95. Review. [PubMed PMID: 20477392]

Schwarz E, Bahn S.
Biomarker discovery in psychiatric disorders.
Electrophoresis. 2008 Jul;29(13):2884-90. Review. [PubMed PMID: 18512679]

Craddock RM, Huang JT, Jackson E, Harris N, Torrey EF, Herberth M, Bahn S.
Increased alpha-defensins as a blood marker for schizophrenia susceptibility.
Mol Cell Proteomics. 2008 Jul;7(7):1204-13. Epub 2008 Mar 18. [PubMed PMID: 18349140]

Lan MJ, McLoughlin GA, Griffin JL, Tsang TM, Huang JT, Yuan P, Manji H, Holmes E, Bahn S.
Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder.
Mol Psychiatry. 2009 Mar;14(3):269-79. Epub 2008 Feb 5. [PubMed PMID: 18256615]

Khaitovich P, Lockstone HE, Wayland MT, Tsang TM, Jayatilaka SD, Guo AJ, Zhou J, Somel M, Harris LW, Holmes E, Pääbo S, Bahn S.
Metabolic changes in schizophrenia and human brain evolution.
Genome Biol. 2008 Aug [pubmed PMID: 18681948]

Schwarz E and Bahn S.
Cerebrospinal fluid: identification of diagnostic markers for schizophrenia.
Expert Rev Mol Diagn. 2008 Mar [pubmed PMID:18366307]

Schwarz E and Bahn S.
The utility of biomarker discovery approaches for the detection of disease mechanisms in psychiatric disorders.
Br J Pharmacol. 2008 Mar; Epub 2008 Jan 14 [pubmed PMID:18193070]

 

2007

Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S.
Gene expression profiling in the adult Down syndrome brain.
Genomics. 2007 Dec; Epub ahead of print [pubmed PMID:17950572]

Huang JT, Wang L, Prabakaran S, Wengenroth M, Lockstone HE, Koethe D, Gerth CW, Gross S, Schreiber D, Lilley K, Wayland M, Oxley D, Leweke FM, Bahn S.
Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues.
Mol Psychiatry. 2007 Oct; Epub ahead of print [pubmed PMID:17938634]

Huang JT, Leweke FM, Tsang TM, Koethe D, Kranaster L, Gerth CW, Gross S, Schreiber D, Ruhrmann S, Schultze-Lutter F, Klosterkotter J, Holmes E, Bahn S.
CSF metabolic and proteomic profiles in patients prodromal for psychosis.
PLoS ONE. 2007 Aug; e756 [pubmed PMID:17712404]

Schwarz E, Levin Y, Wang L, Leweke FM, Bahn S.
Peptide correlation: A means to identify high quality quantitative information in large-scale proteomics studies.
J Sep Sci. 2007 Aug; Epub ahead of print [pubmed PMID:17683046]

Levin Y, Schwarz E, Wang L, Leweke FM, Bahn S.
Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples.
J Sep Sci. 2007 Aug; Epub ahead of print [pubmed PMID:17668910]

Craddock RM, Lockstone HE, Rider DA, Wayland M, Harris LJ, McKenna PJ, Bahn S.
Altered T-cell function in schizophrenia: a cellular model to investigate molecular disease mechanisms.
PLoS ONE. 2007 Aug;2:e692 [pubmed PMID:17668069]

Harris LJW, Swatton JE, Wengenroth M, Wayland M, Lockstone HE, Holland A, Faull RLM, Lilley KS, Bahn S.
Differences in protein profiles in schizophrenia prefrontal cortex compared to other major brain disorders.
Clinical Schizophrenia & Related Psychoses. 2007 Apr;1(1):73-91

Huang JT, McKenna T, Hughes C, Leweke FM, Schwarz E, Bahn S.
CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspects.
J Sep Sci. 2007 Feb;30(2):214-25 [pubmed PMID:17390615]

Tkachev D, Mimmack ML, Huffaker SJ, Ryan M, Bahn S.
Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia.
Int J Neuropsychopharmacol. 2007 Aug; 10(4):557-63. Epub 2007 Feb 12 [pubmed PMID:17291371]

Prabakaran S, Wengenroth M, Lockstone HE, Lilley K, Leweke FM, Bahn S.
2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia.
J Proteome Res. 2007 Jan 5;6(1):141-149 [pubmed PMID:17203958]

2006

Huang JT, Leweke FM, Oxley D, Wang L, Harris N, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Reed B, Bahn S.
Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis.
PLoS Med. 2006 Nov;3(11):e428 [pubmed PMID:17090210]

Wayland MT, Bahn S.
Reproducibility of microarray studies: concordance of current analysis methods.
Prog Brain Res. 2006;158:109-25 [pubmed PMID:17027693]

Holmes E, Tsang TM, Huang JT, Leweke FM, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Nicholson JK, Bahn S.
Metabolic profiling of CSF: Evidence that early intervention may impact on disease progression and outcome in schizophrenia.
PLoS Med. 2006 Aug;3(8):e327 [pubmed PMID:16933966]

Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S.
Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes.
Mol Psychiatry. 2006 Oct;11(10):965-78 [pubmed PMID:16894394]

Somel M, Khaitovich P, Bahn S, Paabo S, Lachmann M.
Gene expression becomes heterogeneous with age.
Curr Biol. 2006 May;16(10):R359-60 [pubmed PMID:16713941]

Tsang TM, Huang JT, Holmes E, Bahn S.
Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.
J Proteome Res. 2006 Apr;5(4):756-60 [pubmed PMID:16602681]

2005

Franz H, Ullmann C, Becker A, Ryan M, Bahn S, Arendt T, Simon M, Paabo S, Khaitovich P.
Systematic analysis of gene expression in human brains before and after death.
Genome Biol. 2005 Dec;6(13):R112 [pubmed PMID:16420671]

Jackson ES, Wayland MT, Fitzgerald W, Bahn S.
A microarray data analysis framework for postmortem tissues.
Methods 2005 Nov;37(3):247-60 [pubmed PMID:16308154]

Agius M, Zaman R, Singh S, Gallagher O, Jones PB, McGuire P, Power P, Craig T, Bahn S, Grech A, Casha C, Pace C, Cassar D, Blinc-Pesek M, Avgustin B, Gruber E, Biocina SM, Andelic J, Dinolova R, van Os J, Lambert M.
Psychiatry in Europe.
Br J Psychiatry. 2005 Jul;187:92 [pubmed PMID:15994586]

2004

Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S. 
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. 
Mol Psychiatry. 2004 Jul;9(7):684-97, 643 [pubmed PMID: 15098003]

Swatton JE, Sellers LA, Faull RL, Holland A, Iritani S, Bahn S.
Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.
Eur J Neurosci. 2004 May;19(10):2711-9 [pubmed PMID: 15147305]

Wilson KE, Ryan MM, Prime JE, Pashby DP, Orange PR, O'Beirne G, Whateley JG, Bahn S, Morris CM.
Functional genomics and proteomics: application in neurosciences.
J Neurol Neurosurg Psychiatry. 2004 Apr;75(4):529-38 [pubmed PMID:15026490]

Mimmack ML, Brooking J, Bahn S. 
Quantitative polymerase chain reaction: validation of microarray results from postmortem brain studies.
Biol Psychiatry. 2004 Feb 15;55(4):337-45 [pubmed PMID: 14960285]

Ryan MM, Huffaker SJ, Webster MJ, Wayland M, Freeman T, Bahn S.
Application and optimization of microarray technologies for human postmortem brain studies.
Biol Psychiatry. 2004 Feb 15;55(4):329-36 [pubmed PMID: 14960284]

Swatton JE, Prabakaran S, Karp NA, Lilley KS, Bahn S. 
Protein profiling of human postmortem brain using 2-dimensional fluorescence difference gel electrophoresis (2-D DIGE).
Mol Psychiatry. 2004 Feb;9(2):128-43 [pubmed PMID: 14708031]

2003

Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, Starkey M, Webster MJ, Yolken RH, Bahn S. 
Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.
Lancet. 2003 Sep 6;362(9386):798-805 [pubmed PMID: 13678875]

2002

Bahn S. 
Gene expression in bipolar disorder and schizophrenia: new approaches to old problems.
Bipolar Disord. 2002;4 Suppl 1:70-2 [pubmed PMID: 12479683]

Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S. 
Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.
Proc Natl Acad Sci USA. 2002 Apr;99(7):4680-5 [pubmed PMID: 11930015]

Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P. 
Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. 
Lancet. 2002 Jan 26;359(9303):310-5 [pubmed PMID: 11830198]

2001

Bahn S, Augood SJ, Ryan M, Standaert DG, Starkey M, Emson PC. 
Gene expression profiling in the post-mortem human brain--no cause for dismay.
J Chem Neuroanat. 2001 Jul;22(1-2):79-94 [pubmed PMID: 11470556]

Ryan M, Starkey M, Faull R, Emson P, Bahn S. 
Indexing-based differential display--studies on post-mortem Alzheimer's brains.
Brain Res Mol Brain Res. 2001 Mar;88(1-2):199-202 [pubmed PMID: 11295249]